What I struggle with is that it’s hard to stay IN a lot of affiliate programs if you don’t do well with them. So in that “building up to 1000s of affiliate programs” stage or when choosing an affiliate program that only really fits in one or two microniche posts, if you’re not already big and converting well, those links won’t do well and a lot of programs will boot you out.
In April 2008 the State of New York inserted an item in the state budget asserting sales tax jurisdiction over Amazon.com sales to residents of New York, based on the existence of affiliate links from New York–based websites to Amazon.[45] The state asserts that even one such affiliate constitutes Amazon having a business presence in the state, and is sufficient to allow New York to tax all Amazon sales to state residents. Amazon challenged the amendment and lost at the trial level in January 2009. The case is currently making its way through the New York appeals courts.
Your domain is the address for your website (e.g., www.affilorama.com) so this is the first thing you will need to do when setting up your site. Considering there are millions of websites on the internet, it's possible that the domain name you want may already be taken by someone else. So make sure you have several options in mind. Be sure to read our advice on how to choose a good domain name. 
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